Clinical Trials by Specialty

ANTICOAGULATION

BRIDGE: Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for an Elective Invasive Procedure or Surgery – For more information, please contact Stephanie at 309-691-4410.

 

CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)/EMPHYSEMA

PNEUMRX: PneumRx RePneu Lung Volume Reduction Coil (RePneu LVRC) System. Lung Volume Reduction coil for treatment in patients with Emphysema (RENEW) study.  For more information, please call Kimberly or Ashley at 309-672-5682.

SPIRATION:  IBV Valve System Humanitarian Device for use in the Control of Air Leaks.  For more information, please call Kimberly or Ashley at 309-672-5682.

 

CORONARY HEART DISEASE/ACS

ABSORB III:  Evaluate the Safety and Effectiveness of the Absorb BVS System Compared to the XIENCE in the Treatment of Subjects, including those with Diabetes Mellitus, with Ischemic Heart Disease caused by up to two De Novo Native Coronary Artery Lesions in separate Epicardial Vessels.  For more information, please contact Stephanie at 309-691-4410.

ODYSSEY: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Effect of SAR236553/REGN727 on the Occurrence of Cardiovascular Events in Patients who have recently experienced an Acute Coronary Syndrome.  For more information, please contact Rita at 309-691-4410.

EXCEL:   Evaluation of XIENCE PRIME™ or XIENCE V® versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization – EXCEL.  For more information, please contact Rita at 309-691-4410.

 

CYSTIC FIBROSIS

VX12-809-103:  A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Lumacaftor in Combination with Ivacaftor in Subjects Ages 12 years and older with Cystic Fibrosis,. Homozygous for the F508del-CFTR Mutation.  For more information please contact Kimberly H. at 309-672-5682.

VX12-809-105:  A Phase 3, Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment with Lumacaftor in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Homozygous or Heterozygous for the F598del-CFTR Mutation.  For more information, please call Kimberly or Ashley at 309-672-5682.

A Point Prevalence Study to Evaluate the Prevalence of Antibodies to Selected Porcine Viruses in Patients with Cystic Fibrosis who are Receiving Porcine Derived Pancreatic Enzyme Replacement Therapy: A Harmonized Protocol Across Sponsors.  For more information please contact Kim H. at 309-655-2189.

 

DIABETES

TRIALNET:  Natural history study of the development of Type I diabetes.  Must be a pediatric or adult patient with a first degree relative diagnosed with Type I diabetes.  For more information, please contact Kimberly H at 309-655-2189.

 

EPILEPSY

LUNDBECK: A prospective, open-label study of the structure and function of the retina in adult patients with refractory complex partial seizures treated with vigabatrin (Sabril®). For more information, please contact Mary 309-624-8401.

 

GASTROPARESIS

ENTERRA: Humanitarian use of the Enterra Therapy Gastric Stimulation System, indicated for the treatment of patients with long term, uncontrolled nausea and vomiting related to gastroparesis. HDE #990014. For more information, please contact Kim D at 309-655-4229.

 

IDIOPATHIC PULMONARY FIBROSIS

INTERMUNE:  Idiopathic Pulmonary Fibrosis - An Open-Label Extension Study of the Long Term Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (IPF).  For more information, please contact Kimberly or Ashley at 309-672-5682.

 

INFECTIOUS DISEASE

Fecal Microbiota Therapy for Treatment of Recurrent Clostridium Difficile Colitis following Standard Antimicrobial TherapyFor more information, please contact April at 309-624-2409.

 

INTERSTITIAL LUNG DISEASE

BRAVE 1: Bronchial Sample Collection for a Novel Genomic Test. For more information, please contact Kimberly or Ashley at 309-672-5682.

BRAVE 2: Bronchial Sample Collection for a Novel Genomic Test-2. For more information, please contact Kimberly or Ashley at 309-672-5682.

 

MULTIPLE SCLEROSIS

STRIVE:  A multicenter, observational, open-label, single-arm study of Tysabri in early relapsing-remitting Multiple Sclerosis in Anti-JCV Antibody Negative patients.  For more information, please contact Kim C at 309-655-4727.

 

NEUROLOGY

Mitochondrial DNA Degradation in Neurologic Disease:   For more information, please contact Kimberly H at 309-655-2189.

HEPATIC ENCEPHALOPATHY: Default mode network fMRI maps as a predictive index of hepatic encephalopathy outcome. For more information, please contact Kim C at 309-655-4727.

 

NEUROSURGERY

DCVax-L 020221:  A phase II clinical trial evaluating DCVax- Brain, autologous dendritic cells pulsed with Tumor Lysate Antigen for the treatment of Glioblastoma Multiforme.  For more information, please contact April at 309-624-2409 or Bridget at 309-655-7837

A prospective study of the relationship of neuropsychological and motor performance parameters with magnetic resonance imaging in athletes with mild traumatic brain injury. For more information, please contact Bridget at 309-655-7837.

HSRT: A Pilot Study Examining the Role of Pre-Operative Hypofractionated Stereotactic Radiation Therapy followed by Surgery in the Treatment of Cerebral Metastatic Disease.  For more information, please contact Bridget 309 655-7837.

MI SPACE:  Clinical Outcomes Following Parafascicular Surgical Evacuation of Intracerebral Hemorrhage: A Pilot Study.  For more information, please contact April at 309-624-2409.

Use of Neuroimaging to Study the Pain Network in Patients of Trigeminal Neuralgia. For more information, contact Bridget at 309 655-7837.

 

PACEMAKER, ICD DEVICE OBSERVATION

MULTIPOINT PACKING IDE:   Evaluate Safety and Efficacy of the Quadripolar CRT-D Device System (with Multipoint Pacing Feature) when Compared to Standard Biventricular Pacing in Patients that are Indicated for a CRT-D Device.  For more information, please contact Stephanie at 309-691-4410.

SJM CLAS:  The purpose of this study is to determine the prevalence of wires being visible outside the lead insulation body (externalized conductors) in the Riata/Riata ST silicone ICD, QuickSite/QuickFlex CRT and Durata ICD leads. For more information, please contact Rita at 309-691-4410.

 

PEDIATRICS

Characterization of Plasma Factor XIII Antigen and Activity in Very Low Birth Weight Premature Neonates: Correlation with the Incidence and Outcome of Intra-ventricular Hemorrhage: A study to measure cord blood antigen concentration and activity of Factor XIII in premature neonates to identify a correlation between low Factor XIII activity and the incidence of intraventricular hemorrhage (IVH). For more information, please contact Kimberly H at 309-655-2189.

The effects of probiotic supplementation on extremely low birth weight infants. For more information, please contact Kim H at 309-655-2189.

Breast Milk Nutrition Analysis – NICU.   For more information, please contact Kim H. at 309-655-2189

 

PULMONARY/CRITICAL CARE

AMGEN (ASTHMA STUDY):  A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Brodalumab in Subjects With Inadequately Controlled Asthma and High Bronchodilator Reversibility.  For more information, please call Kimberly or Ashley at 309-672-5682.  

ART-123:  A randomized, double-blind, placebo-controlled, phase 3 study to assess the safety and efficacy of ART-123 in subjects with severe sepsis and coagulopathy.  For more information, please call Kimberly or Ashley at 309-672-5682.

GSK NAI114373:  Influenza or Influenza-Like-Illness  Title:  A Phase III international, randomized, double-blind, double-dummy study to evaluate the efficacy and safety of 300 mg or 600 mg of intravenous zanamivir twice daily compared to 75 mg of oral oseltamivir twice daily in the treatment of hospitalized adults and adolescents with influenza.  For more information, please contact Kimberly or Ashley 309-672-5682.

SHIRE (ACE INHIBITOR ANGIOEDEMA):  HGT-FIR-096 – A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study Evaluating the Safety and Efficacy of Icatibant as a Treatment for Angiotensin-Converting Enzyme Inhibitor (ACE-I) – Induced Angioedema in Adults.  For more information, please call Kimberly or Ashley at 309-672-5682.

Spectral Diagnostic (US) Inc.:  EUPHRATES:  Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemia and Septic Shock.  For more information, please contact Kimberly or Ashley at 309-672-5682.

 

SICKLE CELL DISEASE

SUSTAIN:   A Phase II, Multicenter, Randomized, Placebo-Controlled, Double-Blind, 12-Month Study to Assess Safety and Efficacy of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients with Sickle Cell-Related Pain Crises (SUSTAIN) SelG1-00005. For more information, please contact Kim H. at 309-655-2189.

 

STROKE

SHINE:  Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial.  For more information, please contact Judi Beck at 309-624-3240. 

 

VASCULAR DEVICE STUDIES

ANCHOR:   Aneurysm Treatment using the HeliFX Aortic Securement System Global Registry.  For more information, please contact Stephanie at 309-691-4410.

ZENITH:  Zenith® TX2® TAA Endovascular Graft Post-Approval Study.  For more information, please contact Stephanie at 309-691-4410.

TIGRIS:  Evaluation of the GORE® TIGRIS Vascular Stent in the Treatment of Atherosclerotic Lesions of the Superficial Femoral and Proximal Popliteal Arteries - For more information, please contact Stephanie at 309-691-4410.

 

For information regarding other clinical trials in the area please visit the following links:

Peoria Radiology Research and Education Foundation
Central Illinois Radiology Associates
http://peoria.medicine.uic.edu/departments___programs/radiology/research/

Illinois Cancer Care
http://www.illinoiscancercare.com/index.cfm?pageID=6

Illinois Lung & Critical Care Institute
http://www.illinoislung.org/

Saint Jude-Midwest Affiliate
http://www.stjuderesearch.org/

Children's Hospital of Illinois
http://www.childrenshospitalofillinois.org/

University of Illinois College of Medicine at Peoria
http://peoria.medicine.uic.edu/research